cas 115940-37-9, 18-ethynylprogesterone | Articles data ｜lookchem

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115940-37-9

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Synthesis of new inhibitors of aldosterone biosynthesis
The synthesis of 18 vinyl and 18 ethynylprogesterone 1 and 2 is described. The reported data emphasize the decisive role played by the protective group on carbon 3 in the course of reactions taking place at the angular 18 methyl group. Compounds 1 and 2, designed as kcat inhibitors of aldosterone biosynthesis late step show substantial in vitro activity.
Viger, Antoinette,Coustal, Suzy,Perard, Serge,Marquet, Andree
p. 1127 - 1134
(2007/10/02)

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Chemical Properties

Melting Point: 130 - 130.5 °C
Boiling Point: 469.7°Cat760mmHg
Flash Point:174.6°C
Density: 1.07g/cm³
Vapor Pressure: 0mmHg at 25°C
PSA: 34.14000
LogP: 5.27970

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