- First generation 5-vinyl-3-pyridinecarbonitrile PKCθ inhibitors
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A series of 5-vinyl-3-pyridinecarbonitriles were synthesized and evaluated as PKCθ inhibitors. The systematic optimization of 4-[(4-methyl-1H-indol-5-yl)amino]-5-[(E)-2-phenylvinyl]-3-pyridinecarbon itrile 3 resulted in the identification of compound 23e
- Niu, Chuansheng,Boschelli, Diane H.,Tumey, L. Nathan,Bhagirath, Niala,Subrath, Joan,Shim, Jaechul,Wang, Yan,Wu, Biqi,Eid, Clark,Lee, Julie,Yang, Xiaoke,Brennan, Agnes,Chaudhary, Divya
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scheme or table
p. 5829 - 5832
(2010/04/28)
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- 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS
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Described herein are compounds of formula I: wherein G is and pharmaceutically acceptable salts thereof, wherein J, X, R1, R2, R11, R12' and p are as defined herein. Also provided herein are methods of making the compounds of formula I, and methods of using these compounds for inhibiting or treating a pathological condition or disorder linked to or mediated by a protein kinase in a mammal.
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Page/Page column 131
(2009/07/17)
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