- Method for synthesizing pyridine bithiazole carboxylic acid derivative
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The invention discloses a method for synthesizing a pyridine bithiazole carboxylic acid derivative. First pyridine bithiazole carboxylic acid is synthesized, a derivative of pyridine bithiazole carboxylic acid is synthesized by replacement, pyridine dihydro thiazole carboxylic acid is generated mainly by reaction between cyanopridine and L-cysteine hydrochloride, and after pyridine dihydro thiazole carboxylic acid forms acyl chloride, amidation or esterification is formed. The synthesis method is simple in the operation process, thiazole can be synthesized without thiazoline, the yield is high, synthesized pyridine bithiazole amide and pyridine bithiazole ester have good bacteriostatic activity and antitumor activity and can be applied well to the fields of medicines and pesticides, and the method provides a new thoughts for creation of novel pesticides.
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Paragraph 0016-0021
(2017/08/23)
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