cas 116632-54-3, 2-Chloro-3-aminoquinoline | Articles data ｜lookchem

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116632-54-3

Articles about 116632-54-3Total 4 be found

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Structure-based design of novel human toll-like receptor 8 agonists
Toll-like receptor (TLR)-8 agonists activate adaptive immune responses by inducing robust production of T helper 1-polarizing cytokines, suggesting that TLR8-active compounds might be promising candidate vaccine adjuvants. Recently, a C2-butyl furo[2,3-c]
Kokatla, Hari Prasad,Sil, Diptesh,Tanji, Hiromi,Ohto, Umeharu,Malladi, Subbalakshmi S.,Fox, Lauren M.,Shimizu, Toshiyoki,David, Sunil A.
p. 719 - 723
(2014)
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TOLL-LIKE RECEPTOR 8 AGONISTS
Compounds described herein can be used for therapeutic purposes. The compounds can be TLR agonists, such as TLR8 agonists. The compounds can be included in pharmaceutical compositions and used for therapies were being a TLR8 agonist is useful. The pharmac
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(2015/07/07)

Design, synthesis and pharmacological evaluation of novel polycyclic heteroarene ethers as PDE10A inhibitors: Part II
We report the design and synthesis of novel pyrrolo[3,2-b]quinoline containing heteroarene ethers as PDE10A inhibitors with good to excellent potency, selectivity and metabolic stability. Further optimization of this primary series resulted in the identif
Das, Sanjib,Shelke, Dnyaneshwar E.,Harde, Rajendra L.,Avhad, Vijayshree B.,Khairatkar-Joshi, Neelima,Gullapalli, Srinivas,Gupta, Praveen K.,Gandhi, Maulik N.,Bhateja, Deepak K.,Bajpai, Malini,Joshi, Ashwini A.,Marathe, Megha Y.,Gudi, Girish S.,Jadhav, Satyawan B.,Mahat, Mahamad Yunnus A.,Thomas, Abraham
supporting information
p. 3238 - 3242
(2014/07/22)

QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
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Page 130

(2008/06/13)

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Chemical Properties

Melting Point: 168℃
Boiling Point: 320℃
Flash Point:147℃
Density: 1.363
PKA: 0.84±0.10(Predicted)
PSA: 38.91000
LogP: 3.05160

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