- Synthesis of 2-aminosuberic acid derivatives as components of some histone deacetylase inhibiting cyclic tetrapeptides
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A new synthesis of the important amino acid 2-aminosuberic acid from aspartic acid is reported. The methodology involves the alternate preparation of (S)-2-aminohept-6-enoate ester as a building block and its diversification through a cross-metathesis reaction to prepare the title compounds. The utility of the protocol is demonstrated through the preparation of three suberic acid derivatives of relevance to the design and the synthesis of peptides of biological relevance.
- Chattopadhyay, Shital Kumar,Sil, Suman,Mukherjee, Jyoti Prasad
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- CALPAIN MODULATORS AND METHODS OF PRODUCTION AND USE THEREOF
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The present technology relates to compounds, kits, compositions, and methods useful for the treatment of fibrotic disease. In some aspects, the present technology provides for treatment of various diseases or disorders associated or mediated, at least in part, by calpains, such as CAPN1, CAPN2, and/or CAPN9. The present technology is generally applicable to compounds which inhibit myofibroblast differentiation.
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Paragraph 00446; 00472
(2017/09/27)
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- Stereoselective total synthesis of alkaloid caulophyllumine B using iterative olefin cross-metathesis protocol
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Herein we report the first total synthesis of alkaloid caulophyllumine B in 14 steps by an iterative olefin cross-metathesis strategy from l-glutamic acid.
- Radha Krishna, Palakodety,Reddy, Bonepally Karunakar
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scheme or table
p. 6262 - 6264
(2011/01/04)
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- PROCESS FOR PRODUCTION OF 4-(SUBSTITUTED PHENYL)HEXAHYDROPYRIDOY2,1-C¨Y1,4¨OXAZIN-6-ONE
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4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one represented by formula (I) or a salt thereof is useful as an intermediate for the production of a bicyclic cinnamide compound which is an Aβ production inhibitor. 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one or the salt thereof can be produced in an industrially advantageous manner by subjecting a compound represented by formula (II) or a salt thereof to an intramolecular condensation reaction.
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Page/Page column 21-22
(2010/09/17)
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