- Efficient copper-catalyzed tandem oxidative iodination and alkyne-azide cycloaddition in the presence of glycine-type ligands
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Tandem oxidative iodination and alkyne-azide cycloaddition reaction has provided one of the most widely used methods for preparation of 5-iodo-1,2,3-triazoles. However, stoichiometric copper salts are involved in this type of reaction in order to enhance
- Yuan, Donghe,Wang, Shilei,Zhu, Gongming,Zhu, Anlian,Li, Lingjun
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- One-pot three-component synthesis of 1,4,5-trisubstituted 5-iodo-1,2,3-triazoles from 1-copper(I) alkyne, azide and molecular iodine
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Copper(I)-catalyzed cycloaddition of 1-iodoalkyne and azide has proven to be the most efficient method for the synthesis of 1,4,5-trisubstituted 5-iodo-1,2,3-triazoles, but pre-made 1-iodoalkyne is required. We find that the combination of 1-copper(I) alk
- Zhang, Jianlan,Chen, Wenwen,Wang, Bo,Zhao, Zhouxing,Wang, Xinyan,Hu, Yuefei
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p. 14561 - 14566
(2015/02/19)
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- Short cut to 1,2,3-triazole-based p38 MAP kinase inhibitors via [3+2]-cycloaddition chemistry
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A series of 4,5-substituted 1,2,3-triazoles was synthesised via Cu(i)-catalysed azide-alkyne 1,3-dipolar [2+3]-cycloaddition reactions followed by a Suzuki coupling. The 1,2,3-triazoles were evaluated as inhibitors of the p38α MAP kinase, showing IC5
- Diner, Peter,Andersson, Terese,Kjellen, Jimmy,Elbing, Karin,Hohmann, Stefan,Grotli, Morten
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experimental part
p. 1010 - 1016
(2010/08/21)
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