An efficient synthesis of cyanoarenes and cyanoheteroarenes via lithiation followed by electrophilic cyanation
A one-pot procedure for the conversion of mono-substituted arenes and heteroarenes into the ortho-cyano derivatives was achieved through directed lithiation followed by electrophilic cyanation with phenyl cyanate. This reaction method proved to be applicable to halogen-lithium exchanged intermediates, so especially useful for the synthesis of benzonitriles. The scope of the reaction sequence was explored using a number of substrates.
Sato, Nobuhiro,Yue, Qi
p. 5831 - 5836
(2007/10/03)
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