Kinetics of Chloromethylation of Benzo-1,4-Dioxane
The chloromethylation of benzo-1,4-dioxane in acetic acid in presence of SnCl4, SbCl3, ZnCl2, and SbCl5 catalysts was investigated.The activation energy of the process was found to be 19.6 kcal/mole.The reaction is zero order in chloride ion and first order in the Hammet acidity function.In excess HCl the reaction is described by a second-order equation.The relative activities of the methyl chlorides in the chloromethylation of benzo-1,4-dioxane were determined.
PYRANOQUINAZOLINE DERIVATIVES AND NAPHTHOPYRAN DERIVATIVES
[Problem] A problem is presented in that conventional photochromic compounds cannot be considered adequate in terms of the colorizing/decolorizing rate and durability, and the production process therefore has many steps. The present invention provides an industrially applicable photochromic compound that has both a rapid colorizing/decolorizing reaction and high durability and can also be synthesized at a low cost. [Solution] This compound is characterized in that etheric oxygen atoms are bonded to the carbon atoms at position 1 of a pyranoquinazoline (8H-pyrano[3,2-f]quinazoline) skeleton and position 10 of a naphthopyran (3H-naphtho[2,1-b]pyran) skeleton, said compound having photochromic properties and being a photochromic compound that has both a rapid colorizing/decolorizing reaction and high durability. Also provided is an industrially applicable photochromic compound that can be synthesized at a low cost.
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(2020/05/14)
PURINE DERIVATIVES AS KINASE INHIBITORS
The present invention provides kinase inhibitors of Formula I.
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Page/Page column 64
(2008/06/13)
N-ACYLAMINO ACID DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS
An N-acylamino acid derivative of the formula: STR1 wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.
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(2008/06/13)
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