- Multicomponent Domino Approaches for the Synthesis of Spirooxazolidine-2-thiones and Spirooxothiolane-2-imines
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A one pot multicomponent protocol is described herein as an approach for construction of spirooxazolidine-2-thiones and spirooxothiolane-2-imines. In a DBU mediated reaction, isatin, phenyl acetylenes, and aryl isothiocyanates undergo hydrothiolation whereas aliphatic isothiocyanates undergo hydroamination. In the presence of a strong base, NaOH for instance, isothiocyanates are exclusively hydrothiolated. This domino approach proceeds by the addition and 5-exo dig cyclization via hydroamination/hydrothiolation, involves consecutive C?C,C?O and C?N/C?S bond formations, the reaction pathway is further studied by DFT calculations.
- Alla, Manjula,Babu Nanubolu, Jagadeesh,Maria Cherian, Arsha,Reddy Indukuri, Divakar,Reddy Potuganti, Gal,Soujanya, Yarasi
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supporting information
p. 5348 - 5358
(2021/10/25)
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- Synthesis of 3-ethynyl-3-hydroxy-2-oxindoles and 3-hydroxy-3-(indol-3-yl) indolin-2-ones using CuWO4 nanoparticles as recyclable heterogeneous catalyst in aqueous medium
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A simple method for the direct activation of phenyl acetylenes (spC-H activation) and selective synthesis of 3-hydroxy-3-(indol-3-yl) indolin-2-ones and 3,3′-bis(indolyl)indolin-2-ones (via Friedel-Crafts alkylation reaction) is reported in presence of Cu
- Paplal, Banoth,Sathish, Kota,Nagaraju, Sakkani,Kashinath, Dhurke
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- Zinc-mediated synthesis of 3-alkynyl-3-hydroxyindolin-2-ones by addition of iodoalkynes to isatins
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An efficient and economical method was developed for synthesis of 3 alkynyl-3-hydroxyindolin-2-ones by addition of iodoalkynes to isatins using zinc dust.
- Singh, Vinay K.,Upadhyay, Abhishek,Singh, Rana Krishna Pal
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supporting information
p. 156 - 158
(2016/12/26)
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- Synthesis and bioactivity evaluation of 3-hydroxy-3-(phenylethynyl)indol-2- one analogues
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A series of propargylic alcohol was synthesized by the addition of phenylacetylene to isatin and its N-substituted derivatives for the first time. This reaction involves activation of zinc reagent via coordination with carbonyl substrates that behave ''li
- Chen, Gang,Wang, Ye,Gao, Suo,He, Hong-Ping,Li, Shun-N,Zhang, Jian-Xin,Ding, Jian,Hao, Xiao-Jiang
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body text
p. 217 - 220
(2009/08/09)
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