Synthesis of All Possible Canonical (3′-5′-Linked) Cyclic Dinucleotides and Evaluation of Riboswitch Interactions and Immune-Stimulatory Effects
The cyclic dinucleotides (CDNs) c-di-GMP, c-di-AMP, and c-AMP-GMP are widely utilized as second messengers in bacteria, where they signal lifestyle changes such as motility and biofilm formation, cell wall and membrane homeostasis, virulence, and exo-elec
Wang, Changhao,Sinn, Malte,Stifel, Julia,Heiler, Anna C.,Sommershof, Annette,Hartig, J?rg S.