- New Manufacturing Route to Picoxystrobin
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A new and efficient manufacturing technology is disclosed in the present work for the preparation of picoxystrobin in which all of the intermediates can be used directly in the next step of the process without purification.
- Chen, Yu,Lu, Huan,Dai, Hui,Yu, Wansheng,Pan, Xianhua
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- A (E)- 2 - (2 - chloromethyl phenyl) - 3 - methoxy methyl acrylate synthesis process (by machine translation)
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A (E)- 2 - (2 - chloromethyl phenyl) - 3 - methoxy methyl acrylate synthesis process, including: (1) condensation; (2) the etherification reaction; (4) chloride; (5) secondary desolvation; (6) ester; (7) washing, extraction; (8) desolvation, recrystallized; the advantage of this invention is: to 3 - different chromone (3 - different benzene and dihydro pyrone) and formic acid methyl ester as the raw material, by condensation reaction generating hydroxyl (4 - (hydroxy armor alkene base) - 3 - ISO benzopyranone); hydroxyl with dimethyl sulfate etherification reaction to produce armor oxygen (4 - (methoxy armor alkene base) - 3 - ISO benzopyranone); a homogenize the chlorination reaction with thionyl chloride to produce the acyl chloride (2 - (2 - chloromethyl phenyl) - 3 - methoxy acryloyl chloride); acyl chloride and methanol to carry out the esterification reaction to produce 2 - (2 - chloromethyl phenyl) - 3 - methoxy methyl acrylate, the process is applicable for large-scale industrial production, pollution is small, energy saving and environmental protection. (by machine translation)
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Paragraph 0039; 0048; 0051; 0058-0060
(2018/01/04)
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- A (E) - 2 - (the 2 [...] -chloromethyl) phenyl-3-methoxy methyl acrylate preparation method
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The invention discloses a novel preparation method of (E)-2-(2'-chloromethyl) phenyl-3-methoxy methyl acrylate. The preparation method comprises the following steps: with 3-isochromanone as a starting material, under actions of trimethyl orthoformate and glacial acetic acid, performing condensation reaction to obtain an intermediate, and reacting the intermediate with thionyl chloride and methanol in sequence to obtain the (E)-2-(2'-chloromethyl) phenyl-3-methoxy methyl acrylate. According to the preparation method, the process is relatively simple, the raw materials are easy to obtain, the cost is low, the solid, liquid and gas wastes are few, and the content and yield of the target product are relatively high, and the method is suitable for industrial production.
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Paragraph 0031; 0032
(2016/11/14)
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- Process for producing acrylic acid derivative
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Processes for producing a compound represented by the formula (1), which includes an acrylic acid derivative and is useful as an agricultural chemical or medicine. One of the processes comprises the step of formulating a compound (3) and converting the OH of the resultant compound (2) into OR″. The first step comprises reacting a formic or orthoformic ester in the presence of a Lewis acid and a base. The second step comprises reacting the compound with R″OH or with R″OH and CH(OR″)3 under acidic conditions or using a phase-transfer catalyst in a two-phase system and regulating the base and the concentration thereof to stereoselectively synthesize the target compound. In another, process, the compound is efficiently produced without isolating the compound. The compound can also be produced without the compound (2).
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- PROCESSES FOR PRODUCING ACRYLIC ACID DERIVATIVE
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Processes for producing a compound (1) represented by formula (1), which includes an acrylic acid derivative and is useful as an agricultural chemical or medicine. One of the processes comprises the step of formylating a compound (3) (step (1)) and the step of converting the OH of the resultant compound (2) into OR" (step (2)). The step (1) comprises reacting a formic or orthoformic ester in the presence of a Lewis acid and a base. The step (2) comprises [1] reacting the compound (2) with R" OH or with R" OH and CH(OR")3under acidic conditions or [2] using a phase-transfer catalyst in a two-phase system and regulating the base and the concentration thereof to stereoselectively synthesize the target compound. In another process, the compound (1) is efficiently produced without isolating the compound (2). In still another process, the compound (1) is directly produced without via the compound (2).
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- Chemical intermediates useful in agriculture
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Intermediates of formula (I), STR1 wherein R is H or CH3 ; processes for preparing them and their use as chemical intermediates, especially for preparing fungicidal acrylic ester derivatives.
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- Fungicides
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Fungicidal compounds of the formula (I): STR1 and stereoisomers thereof, wherein R1 is optionally substituted aryl or optionally substituted heteroaryl; Y is oxygen, sulphur or NR4 ; R2, R3 and R4, which may be the same or different, are hydrogen, C1-4 alkyl or C2-4 alkenyl; X is halogen, C1-4 alkyl, C2-4 alkenyl, C1-4 alkoxy, nitro or cyano; and n is 0 or an integer of 1 to 4; provided that when Y is oxygen, n is O and R1 is unsubstituted phenyl at least one of R2 and R3 is other than hydrogen or methyl.
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