- 2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors
-
The identification of class II HDAC inhibitors has been hampered by lack of efficient enzyme assays, in the preceding paper two assays have been developed to improve the efficiency of these enzymes: mutating an active site histidine to tyrosine, or by the
- Jones, Philip,Bottomley, Matthew J.,Carfi, Andrea,Cecchetti, Ottavia,Ferrigno, Federica,Lo Surdo, Paola,Ontoria, Jesus M.,Rowley, Michael,Scarpelli, Rita,Schultz-Fademrecht, Carsten,Steinkuehler, Christian
-
scheme or table
p. 3456 - 3461
(2009/04/05)
-
- CONVENIENT SYNTHETIC EQUIVALENTS OF 2-LITHIOPYRROLE AND 2,5-DILITHIOPYRROLE.
-
Bromination of pyrrole by 1,3-dibromo-5,5-dimethylhydantoin, followed by direct reaction with BOC anhydride and DMAP, affords the stable N-BOC derivatives of 2-bromopyrrole and 2,5-dibromopyrrole.Lithium-halogen exchange of the latter with n-butyllithium generates the N-BOC derivatives of 2-lithiopyrrole, 2,5-dilithiopyrrole or 5-bromo-2-lithiopyrrole,which react with various electrophiles to give substituted N-BOC pyrroles in excellent yield.
- Chen, Wha,Cava, Michael P.
-
p. 6025 - 6026
(2007/10/02)
-