1,3-Dipolar Cycloaddition Reactions of 1-Aryl-N-methyl-2-(1H-azol-1-yl)-ethanimine N-Oxides to Olefins
The regio- and stereoselectivity of the 1,3-dipolar cycloaddition reaction of 1-aryl-N-methyl-2-(1H-azol-1-yl)ethanimine N-oxides 6 to monosubstituted olefins 7 were investigated.The reaction is regioselective, leading to the corresponding C-5 substituted isoxazolidines 8/9 as cis/trans diastereomeric mixtures.The cis isomers, which are the predominant species of the mixtures, are readily separated by flash chromatography on neutral silica gel.
Mullen, George B.,Bennett, Grace A.,Swift, Patricia A.,Marinyak, David M.,Dormer, Peter G.,Georgiev, Vassil St.
p. 105 - 107
(2007/10/02)
Studies on antifungal agents 30. Novel substituted 3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-phenyl(or phenyloxymethyl)-isoxazolidines
The synthesis of a novel class of antifungal agents, the 3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-phenyl(or phenoxymethyl)isoxazolidines (10-15) is described.When tested in vitro, derivatives 10-15 exerted a potent antifungal activity against d
Bennett, Grace A.,Mullen, George B.,Mitchell, Jeffrey T.,Jones, Wendy E.,Allen, Stanley D.,et al.
p. 579 - 584
(2007/10/02)
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