A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site
(Figure Presented) DAPper ligands: The 3,5-diaminopiperidine (DAP) heterocycle has been developed as a structural mimetic of the RNA-recognizing pharmacophore of the 2-DOS scaffold. Here we describe the synthesis of novel modular DAP ligands that bind to a conformational target in the internal ribosome entry site RNA of the hepatitis C virus.
Carnevali, Maia,Parsons, Jerod,Wyles, David L.,Hermann, Thomas
p. 1364-1367+1315
(2011/04/24)
ANTIVIRAL COMPOUNDS FOR THE TREATMENT OF HCV INFECTION
Disclosed are compounds and methods of synthesis of Formula I for the development of antiviral drugs for the treatment of HCV infection.
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Page/Page column 48
(2009/10/09)
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