- Derivatives of m-Guaiacol, Their Preparation and Their Uses
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The invention concerns derivatives of m-guaiacol, their preparation and their uses as biocides, in particular as antibacterials or disinfectants.
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Paragraph 0125; 0127
(2021/11/05)
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- 3,5-DISUBSTITUTED PYRAZOLES USEFUL AS CHECKPOINT KINASE 1 (CHK1) INHIBITORS, AND THEIR PREPARATIONS AND APPLICATIONS
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Potent inhibitors of Chk1 have the structure formula (I) below. Pharmaceutical compositions comprising the Chk1 inhibitors, uses thereof and their preparation process.
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Paragraph 000102
(2018/02/28)
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- Investigation of (E)-3-[4-(2-oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic acids as oral selective estrogen receptor down-regulators
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A novel estrogen receptor down-regulator, 7-hydroxycoumarin (5, SS5020), has been reported with antitumor effects against chemically induced mammary tumors. Here, we report on our own investigation of 7-hydroxycoumarins as potential selective estrogen rec
- Degorce, Sébastien L.,Bailey, Andrew,Callis, Rowena,De Savi, Chris,Ducray, Richard,Lamont, Gillian,MacFaul, Philip,Maudet, Mickael,Martin, Scott,Morgentin, Rémy,Norman, Richard A.,Peru, Aurélien,Pink, Jennifer H.,Plé, Patrick A.,Roberts, Bryan,Scott, James S.
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supporting information
p. 3522 - 3533
(2015/05/05)
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- TRIAZOLES AS KV3 INHIBITORS
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Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.
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Page/Page column 70 ; 71
(2014/01/07)
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- PROCESSES FOR PRODUCING 1-BROMO-2 (CYCLOPROPYL METHOXY)-5 FLUORO-4- METHOXYBENZENE
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This invention provides new processes for the preparation of 1-bromo-2- (cyclopropyl methoxy)-5-fluoro-4-methoxybenzene and for the preparation of an intermediate, 4- f!uoro-3-methoxyphenol.
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Page/Page column 2; 3; 4
(2012/03/26)
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- CARBOXAMIDE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS
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The invention relates to compounds of Formula (I) processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical composition containing them.
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Page/Page column 48
(2008/06/13)
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- FACILE PREPARATIONS OF 4-FLUORORESORCINOL
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Two facile methods for preparing 4-fluororesorcinol have been developed.In the first method, the direct fluorination of 1,3-dimethoxybenzene with trifluoromethyl hypofluorite carried out in Freon 11 at -78 deg C afforded 2,4-dimethoxyfluorobenzene.Demethylation by heating under reflux in 48percent HBr in acetic acid gave 4-fluororesorcinol in an overall yield of 60percent.The second method involved the fluorination of 2,6-dimethoxycetophenone by trifluoromethyl hypofluorite in Freon 11 at -78 deg C, leading to 2,6-dimethoxy-3-fluorocetophenone.On heating under reflux in 48percent HBr in acetic acid, 4-fluororesorcinol was obtained in an overall yield of 74percent.The latter is the method of choice for preparing 4-fluororesorcinol.
- Belanger, Patrice C.,Lau, C. K.,Williams, Haydn W. R.,Dufresne, C.,Scheigetz, John
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p. 1479 - 1482
(2007/10/02)
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