- The base-promoted synthesis of multisubstituted benzo[b][1,4]oxazepines
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A novel protocol to synthesize multisubstituted benzo[b][1,4]oxazepines from N-(2-haloaryl)enaminones has been developed. In this procedure, only 2 equiv. of Cs2CO3 was required. A variety of polysubstituted benzo[b][1,4]oxazepine derivatives were provided in up to 95% yield for 27 examples.
- Shen, Jinhai,Xue, Lulu,Lin, Xing,Cheng, Guolin,Cui, Xiuling
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- 3-Aroylindoles via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones
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3-Aroylindoles have been prepared via copper-catalyzed cyclization of N-(2-iodoaryl)enaminones, readily available from 2-iodoanilines and α,β-ynones. The reaction tolerates a variety of useful functionalities including ether, keto, cyano, bromo, and chlor
- Bernini, Roberta,Cacchi, Sandro,Fabrizi, Giancarlo,Filisti, Eleonora,Sferrazza, Alessio
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body text
p. 1480 - 1484
(2009/10/17)
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- Copper-catalyzed C-C bond formation through C-H functionalization: Synthesis of multisubstituted indoles from N-aryl enaminones
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A variety of functionalities, including the whole range of halogen substituents, are tolerated in the title reaction, an intramolecular approach for the construction of a multisubstituted indole skeleton from readily available enaminones (see scheme; phen=1,10-phenanthroline). The indole products are also prepared directly in high yield from α, β-ynones and primary amines.
- Bernini, Roberta,Fabrizi, Giancarlo,Sferrazza, Alessio,Cacchi, Sandro
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supporting information; experimental part
p. 8078 - 8081
(2010/01/16)
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