- Method for continuously synthesizing isooctyl salicylate in microchannel (by machine translation)
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To the method, salicylic acid and isooctanol are used as a raw material to synthesize the. isooctyl salicylate to the synthesis of isooctyl salicylate in, the microchannel for a short, time in the process of flowing. (by machine translation)
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Paragraph 0022-0027
(2020/01/14)
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- SKIN WHITENING AGENT CONTAINING NOVEL CYCLIC COMPOUND
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Provided is a derivative or a polyhydroxy cyclic compound represented by Formula I or a pharmacologically acceptable salt thereof with excellent whitening effects, comprising; wherein {circle around (A)} is derived from an aromatic cyclic compound, B is hydrogen, oxo (═O), amino (—NH2), imino (═NH), or a saturated or unsaturated straight or branched alkyl, alkoxy, monoalkylamino, or dialkylamino group having 1 to 10 carbon atoms, Cn, Cn+1and Cn+2 are three neighboring carbon atoms present in the aromatic cyclic compound, wherein n is a positive integer, R1 is hydrogen, hydroxy, or a saturated or unsaturated straight or branched alkyl or alkoxy group, X and Y are selected from a group consisting of hydrogen, hydroxy, and a saturated or unsaturated straight or branched alkoxy, or acyloxy group, and one of X and Y is hydrogen, R2, R3, R4 and R5 are each independently at least one substituent selected from a group consisting of hydrogen, alkyl, alkoxy, acyloxy, acyloxymethyl, oxo, hydroxy, vinyl, nitrile, carboxaldehyde, carbonitrile and aldehyde.
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Paragraph 0162; 0163
(2016/08/29)
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- A method for production of salicylic acid isooctyl
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The invention provides a method for industrially producing ethylhexyl salicylate. The method comprises the steps of esterifying salicylic acid and isooctyl alcohol in an n-heptane solvent under sodium hydrogen sulfate serving as a catalyst to synthesize a coarse ethylhexyl salicylate product, and enabling the salicylic acid conversion rate to be greater than or equal to 99 percent and the isooctyl ether generation amount to be less than 1 percent by controlling the backflow temperature to be 110+/-5 DEG C and the backflow water division time to be 8-10 hours; then performing decompression rectification, effectively separating impurities with different boiling points by controlling the temperature of circulating water of a built-in backflow condenser to obtain a high-purity ethylhexyl salicylate product, wherein the product yield is greater than or equal to 95 percent, and the purity of a product detected by GC (gas chromatography) is greater than or equal to 99.5 percent. The esterifying synthesized catalyst and the non-reacted salicylic acid can be both recycled and directly used for synthesis of the next batch, so that raw materials are saved and the cost are reduced. The synthesis method is reasonable in design, easy to operate and suitable for being popularized and industrialized.
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Paragraph 0059-
(2017/04/11)
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- PROCESS FOR TREATING SOL-GEL CAPSULES
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The present invention relates to a process for treating sol-gel capsules comprising a cosmetic or pharmaceutical active material with an inorganic material, as well as sol-gel capsules produced by a process according to the present invention and formulations comprising such sol-gel capsules.
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- Flavonoid derivative
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The invention relates to a novel flavonoid derivative, to an extract comprising the flavonoid derivative, to the cosmetic and pharmaceutical use thereof, to preparations comprising the flavonoid derivative or extract, and to a process for the preparation of the flavonoid derivative or extract.
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- Use of ectoin or ectoin derivatives for protecting stress proteins in the skin
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The present invention relates to the use of at least one compound selected from the group comprising compounds of formulas 1a and 1b physiologically acceptable salts thereof, and stereoisomeric forms thereof, in which R1 denotes H oder alkyl, R2 denotes H, COOH, COO-alkyl or CO—NH—R5, R3 and R4 each independently denote H or OH, n is 1, 2 or 3, R5 denotes H, alkyl, an amino acid group, a dipeptide residue or a tripeptide residue, and alkyl denotes an alky group containing from 1 to 4 carbons, for protection of stress proteins in the skin. These compounds are used in the present invention in the form of a topical composition.
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- Use of aryl oximes for the prophylaxis and/or treatment of erythema formation and/or inflammatory reaction of the skin
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The present invention relates to the use of at least one aryl oxime of Formula (I). wherein: Y, Z represent independently from each other H, C1-18 alkyl, C2-18 alkenyl, C2-18 carboxy alkyl, C3-18 carboxy alkenyl or C2-18 alkanoyl; R represents C1-18 alkyl, C2-18 alkenyl, C3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R1, R2, R3 and R4 represent independently from each other H, C1-12 alkyl, C2-12 alkenyl, C1-12 alkoxy, C3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl, for the prophylaxis and/or treatment of erythema formation and/or inflammation responses of the skin.
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- Topical composition containing at least one aryl oxime, and method for the preparation thereof
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The present invention relates to a topical composition, comprising (c) at least one aryl oxime of the Formula (I) and (d) at least one emulsifier, wherein: Y, Z represent independently from each other H, C1-18 alkyl, C2-18 alkenyl, C2-18 carboxy alkyl, C3-18 carboxy alkenyl or C2-18 alkanoyl; R represents C1-18 alkyl, C2-18 alkenyl, C3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R1, R2, R3 and R4 represent independently from each other H, C1-12 alkyl, C2-12 alkenyl, C1-12 alkoxy, C3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl, wherein the component (b) is selected from the group consisting of an ester, the carboxylic acid residue of which is derived from C5-C16 acids and the hydroxyl residue of which is derived from monomers, dimers or trimers of lactic acid or one of its salts or a polyglycerin of 2 to 10 molecules of glycerin whereby 1 to 3 moles of carboxylic acid are present per mole of polyglycerin. Furthermore, the present invention relates to a process for the preparation of said topical composition as well as the use of said topical composition.
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- Composition containing at least one aryl oxime and at least one active substance for treating acne and the use thereof
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The present invention relates to a composition, comprising (a) at least one aryl oxime of Formula (I) and (b) at least one active agent for the treatment of acne ?wherein: Y, Z represent independently from each other H, C1-18 alkyl, C2-18 alkenyl, C2-18 carboxy alkyl, C3-18 carboxy alkenyl or C2-18 alkanoyl; R represents C1-18 alkyl, C2-18 alkenyl, C3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R1, R2, R3 and R4 represent independently from each other H, C1-12 alkyl, C2-12 alkenyl, C1-12 alkoxy, C3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl. Moreover, the present invention relates to the use of this composition as well as the use of the aforementioned aryl oxime of Formula (I).
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- Use of ectoin or ectoin derivatives for the prophylaxis and/or treatment of uv-induced immunosuppression
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The present invention relates to the use of at least one compound selected from the group comprising compounds of formulas 1a and 1b physiologically acceptable salts thereof and stereoisomeric forms thereof, in which R1 denotes H oder alkyl, R2 denotes H, COOH, COO-alkyl or CO—NH—R5, R3 and R4 each independently denote H or OH, n is 1, 2 or 3, R5 denotes H, alkyl, an amino acid group, a dipeptide residue or a tripeptide residue, and alkyl denotes an alkyl group containing from 1 to 4 carbons, for the prophylaxis and/or treatment of immunosuppression. These compounds are used in the present invention in the form of a topical composition.
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- Use of ectoin or ectoin derivatives for stabilizing p53
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This invention relates to the use of at least one compound, selected from a compound of the formula 1a, 1b, 1a physiologically compatible salt of it and a stereoisomeric form of it, whereby the following signify R1 H or alkyl, R2 H, COOH, COO-alkyl or CO—NH—R5, R3 and R4 each mutually independent H or OH, n 1, 2 or 3, R5 H, alkyl, an amino acid residue, a dipeptide residue or tripeptide residue, and alkyl an alkyl residue with 1 to 4 carbon atoms, for the stabilisation of p53. According to the invention, these compounds are normally used in the form of a topical composition.
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- Method for producing luteolin and luteolin derivatives
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Disclosed is a method for producing compounds of formula (I), wherein R1represents H or (CH2)mOH, R2represents H or (CH2)nOH, R3represents H or (CH2)pOH and m, n and p represent 2-8 independently from one another. Said compounds are particularly suitable for use as food supplements. They are highly suitable for use in cosmetic formulations as UV filters, for instance.
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- Formulation for protection against oxidative stress containing benzofuranone derivatives
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The invention relates to a cosmetic or pharmaceutical formulation comprising at least one compound of formula (I). The cosmetics or pharmaceutical products are particularly suitable for the care of the skin in protecting against oxidative stress and ageing phenomena.
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- Preparation containing quinoxaline derivatives
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The invention relates to the use of quinoxaline derivatives as photostable UV filters in cosmetic and pharmaceutical preparations for protecting the human epidermis or human hair against UV radiation, especially in the 280-400 nm range.
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- Galenic formulation
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Cosmetic or dermatological formulations which comprise one or more active ingredients selected from phylloquinone, 2-hydroxy-5-methyllaurophenone oxime, vitamin A and its derivatives, vitamin E and its derivatives, vitamin H, allantoin, bisabolol, nicotinic acid derivatives and caffeine and in addition (a) one or more antioxidants and/or (b) one or more UV filters, are distinguished, in particular, by the fact that the active ingredients present in the formulation according to the invention are stabilised.
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- Galenical formulation
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The invention relates to compounds of the formula I 1where R1, R2, R3, R4 and R5 have the meanings given in claim 1. The compound is suitable in particular for use in skin care compositions. They protect, firstly, against harmful oxidation reactions and, secondly, also act as UV filters.
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- Indanylidene compounds, a process for their preparation and their use as UV absorbers
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Compounds of the formula I according to claim 1 are excellently suitable as UV absorbers for use in cosmetic products, in particular sunscreen compositions, daytime care products and hair care products. They are furthermore suitable for protection of products.
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- Transparent cosmetic composition that reflects infrared radiation and its use for protecting the human epidermis against infrared radiation
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Transparent cosmetic composition that reflects infrared radiation and its use for protecting the human epidermis against infrared radiation. The invention relates to a transparent cosmetic composition comprising, by way of an agent that reflects infrared radiation for protecting the human epidermis, a substance which is dispersible in the cosmetic medium used, possessing a reflectance (R) of infrared radiation equal to at least 45%, and of which a 2% strength dispersion in vaseline possesses an optical transmission in the visible of at least 85%, chosen from a diatom of particle size less than 100 microns, hollow glass microspheres of size less than 100 microns, a bismuth oxychloride of particle size less than 75 microns and zirconium powder covered ceramic microparticles of particle size less than 8 microns. This cosmetic composition can also contain 0.5 to 20% by weight of UV-A, UV-B or broad-band screening agents.
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- Cosmetic screening composition containing a UV screen in combination with a polymer obtained by block polymerization in emulsion and its use for the protection of the human epidermis against ultraviolet radiations
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Cosmetic screening composition containing a UV screen in combination with a polymer obtained by block polymerization in emulsion and its use for the protection of the human epidermis against ultraviolet radiations.
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- Sunscreen method containing polyisobutylene for the protection of human epidermis against ultraviolet radiations
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The present invention relates to a sunscreen composition containing at least one oil-soluble agent absorbing UV rays as well as at least one polyisobutylene which is liquid at ambient temperature, with a viscosity-average molecular weight of between 8,000 and 65,000, in a cosmetically acceptable medium incorporating at least one fatty phase. Such a suncreen composition, applied on the skin, has an improved protection index.
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