- INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF
-
The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
- -
-
-
- Gonadotropin releasing hormone receptor antagonists
-
The present invention relates to Gonadotropin Releasing Hormone (“GnRH”) (also known as Leutinizing Hormone Releasing Hormone) receptor antagonists.
- -
-
Page/Page column 33
(2010/02/15)
-
- MALONONITRILE COMPOUND AS PESTICIDES
-
The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X1, X2, X3 and X4 is CR100, wherein R100 is a group represented by the formula: the other three of X1, X2, X3 and X4 each represent nitrogen or CR5, provided that 1 to 3 of X1, X2, X3 and X4 represent nitrogen, and Z represents oxygen, sulfur or NR6, which has pest-controlling activity.
- -
-
Page/Page column 201-202
(2008/06/13)
-
- NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
-
The present invention relates to novel compounds of formula (I) wherein W, n, X and W’ are defined in the description; invention compounds are modulators of metabotropic glutamate receptors - subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.
- -
-
Page/Page column 126
(2008/06/13)
-
- Reaction of 1,3-dibromo- and 1,3-dichloroacetone with 2-aminoazaheterocycles
-
The reactions of 1,3-dibromoacetone with 2-aminoazines and 2-aminoazoles has been carried out for the first time and the pure intermediate quaternary salts have been isolated. They undergo cyclization to the corresponding imidazoazines and imidazoazoles containing a bromomethyl group. Similar condensations were carried out with 1,3-dichloroacetone.
- Kovalenko,Kutrov,Filipchuk,Kornilov
-
p. 590 - 597
(2007/10/03)
-