A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.
Asaad, Nabil,Bethel, Paul A.,Coulson, Michelle D.,Dawson, Jack E.,Ford, Susannah J.,Gerhardt, Stefan,Grist, Matthew,Hamlin, Gordon A.,James, Michael J.,Jones, Emma V.,Karoutchi, Galith I.,Kenny, Peter W.,Morley, Andrew D.,Oldham, Keith,Rankine, Neil,Ryan, David,Wells, Stuart L.,Wood, Linda,Augustin, Martin,Krapp, Stephan,Simader, Hannes,Steinbacher, Stefan
scheme or table
p. 4280 - 4283
(2010/04/30)
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