- Studies of one-pot double couplings on dibromoquinolines
-
In a series of studies, the regioselectivity of Suzuki couplings of dibromoquinolines has been investigated. In general, it is much harder to achieve high levels of regioselectivity in these systems compared to many of the other dibromoheteroaromatics that have been studied. Useful levels of selectivity could be achieved for both a 5,7-dibromoquinoline as well as 3,4-dibromoquinoline. Double Suzuki couplings could also be achieved on these two compounds.
- Piala, Alexander,Mayi, Diyar,Handy, Scott T.
-
p. 4147 - 4154
(2011/07/08)
-
- HYDRAZONE COMPOUNDS AND THEIR USE
-
The present invention relates to hydrazone compounds of Formula I: (I) and pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3, R4, L1, and L2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I as inhibitors of TRPM5 protein.
- -
-
Page/Page column 139
(2010/12/17)
-