- PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof
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Platelet Activating Factor (PAF) antagonists which comprises the compounds of the formula (I): wherein A is an optionally substituted phenyl or an optionally substituted heterocyclic group; X is methylene group, carbonyl group or thiocarbonyl group; R1, R2 and R3 are independently a lower alkyl group, and their salts are excellent in absorption from the intestinal canal. Among the compounds of the formula (I), those wherein A is an optionally substituted 2,3-dihydro-1-benzoxepin-4--yl group are novel compounds and exhibit excellent PAF antagonism.
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- PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof
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Platelet Activating Factor (PAF) antagonists which comprise the compounds of the formula (I): STR1 wherein A is an optionally substituted phenyl or an optionally substituted heterocyclic group; X is methylene group, carbonyl group or thiocarbonyl group; R1, R2 and R3 are independently a lower alkyl group, and their salts are excellent in absorption from the intestinal canal. Among the compounds of the formula (I), those wherein A is an optionally substituted 2,3-dihydro-1-benzoxepin-4-yl group are novel compounds and exhibit excellent PAF antagonism.
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- 1,4-disubstituted piperazines (or homopiperazines) as platelet-activating factor antagonists
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Novel 1,4-disubstituted piperazine compounds represented by the formula (I): STR1 wherein A is a condensed polycyclic hydrocarbon group; R is a phenyl group substituted with a lower alkoxy group; X is methylene group, carbonyl group or thiocarbonyl group; and m is 2 or 3, and their salts are useful as a platelet activating factor antagonist.
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