Benzimidazole or azabenzimidazole -6 - carboxylic acid compound and application thereof
The invention discloses benzimidazole or azabenzimidazole -6 - carboxylic acid compound and application thereof, wherein the benzimidazole or azabenzimidazole -6 - carboxylic acid compound has the structure shown in the formula (I). The benzimidazole or a
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Paragraph 0350-0352; 0354
(2021/10/11)
2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS
Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): (IA) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
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(2020/07/08)
MODULATORS OF DOPAMINE NEUROTRANSMISSION
The present invention relates to novel1-(4H-1,3-benzodioxin-2-yl)methanamine derivatives, useful as modulators of dopamine neurotransmission, and more specifically asdopaminergic stabilizers. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
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(2009/12/05)
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