- TREATMENT OF DISEASES BY EPIGENETIC REGULATION
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The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.
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Paragraph 0501; 0502
(2013/11/05)
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- NOVEL ANTI-INFLAMMATORY AGENTS
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Disclosed are methods of regulating interleukin-6 (IL-6) and/or vascular cell adhesion molecule-1 (VCAM-1) and methods of treating and/or preventing cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s) by administering a naturally occurring or synthetic quinazolone derivative. The invention provides novel synthetic quinazolone compounds, as well as pharmaceutical compositions comprising those compounds.
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Page/Page column 105-106
(2010/11/05)
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- QUINOLINE DERIVATIVES
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The invention concerns quinoline derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
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Page/Page column 105
(2008/06/13)
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- (R,R) AND (S,S) 2,5-DIAZABICYCLO [2,2,1]HEPTANE DERIVATIVES
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Compounds of the Formulae I or II STR1 wherein Z and R 1, are as described herein which compounds are muscarinic agonists useful in treating central cholinergic disfunction and pharmaceutical compositions containing the compounds.
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- 3-Substituted-1,2,4-Oxadiazolin-5-one; A Useful Amidine Precursor and Protecting Group
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5-Benzyloxy-1,2,4-oxadiazoles and 1,2,4-oxadiazolin-5-ones are useful precursors to, and protecting groups for the amidine moiety.The latter compounds are readily prepared from amidoximes or alternatively via cycloaddition of nitrile oxides to trichloroac
- Bolton, Richard E.,Coote, Steven J.,Finch, Harry,Lowdon, Andrew,Pegg, Neil,Vinader, M. Victoria
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p. 4471 - 4474
(2007/10/02)
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