- MICROBIAL OXIDATION IN SYNTHESIS: PREPARATION OF MYO-INOSITOL PHOSPHATES AND RELATED CYCLITOL DERIVATIVES FROM BENZENE.
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Pseudomonas putida oxidation of benzene affords cis-3,5-cyclohexadiene-1,2-diol (2) which is used as a novel precursor for the synthesis of D- and L-myo-inositol 1,4,5-triphosphates, (-)-(1) and (+)-(1).The versatility of this approach to functionalised cyclitols is illustrated in the synthesis of myo-inositol 1-phosphate (19), 6-deoxy, 6-deoxy-6-fluoro, and 6-deoxy-6-methyl myo-inositols (31), (37) and (43), and their 1,4,5-trisphosphate derivatives (33), (39) and (45).
- Ley, Steven V.,Parra, Margarita,Redgrave, Alison J.,Sternfeld, Francine
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p. 4994 - 5026
(2007/10/02)
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- MICROBIAL OXIDATION IN SYNTHESIS: PREPARATION FROM BENZENE OF THE CELLULAR SECONDARY MESSENGER MYO-INOSITOL-1,4,5-TRISPHOSPHATE(IP3) AND RELATED DERIVATIVES
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Following microbial oxidation of benzene with Pseudomonas putida the resulting cis-1,2-dihydroxycyclohexa-3,5-diene may be converted to the cellular secondary messenger myo-inositol-1,4,5-trisphosphate(IP3) and its 6-methyl derivative.
- Ley, Steven V.,Sternfeld, Francine
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p. 5305 - 5308
(2007/10/02)
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