Synthetic access to poly-substituted 6-alkoxyindoles from 1,3-cyclohexanediones and nitroolefins through facile aromatization reaction
(Chemical Equation Presented) 6-Alkoxy-3-arylindoles were efficiently prepared from 1,3-cyclohexanedione enol ethers and β-nitrostyrenes. Michael addition using the kinetically generated enolate, followed by Zn reduction of a nitro group of the resulting
Ma, Li-Jian,Li, Xiao-Xia,Kusuyama, Tomoyo,El-Sayed, Ibrahim El-Tantawy,Inokuchi, Tsutomu