Ring expansion of cyclic β-amino alcohols induced by diethylaminosulfur trifluoride: Synthesis of cyclic amines with a tertiary fluorine at C3
As the replacement of a hydrogen atom by a fluorine atom in a compound can have an important impact on its biological properties, the development of methods allowing the introduction of a fluorine atom is of great importance. The scope and limitations of
NOVEL ASYMMETRIC ALKYLATION OF CYCLIC β-KETO ESTERS WITH OPTICALLY ACTIVE SULFONIUM SALTS
A new asymmetric alkylation of cyclic β-keto esters with optically active sulfonium salts, which are easily prepared by optical resolution methods, has been investigated.Relative reactivities for alkyl substituents are found to be quite different from tho