Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles
Optimisation of the potency of a bicyclic CRF antagonist whilst retaining metabolic stability is described. A core change and incorporation of metabolically stable lipophilic groups resulted in a further potency gain without increasing metabolic liability
Miller, Duncan C.,Klute, Wolfgang,Brown, Alan D.
p. 6108 - 6111
(2011/11/06)
NOVEL COMPOUNDS
The present invention relates to a class of substituted purine compounds of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These compounds have utility in a variety of therapeutic areas including sexual dysfunction.(I).
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(2009/12/27)
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