Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists
The transient receptor potential A1 (TRPA1) channel has been implicated in a number of inflammatory and nociceptive processes, and antagonists of the TRPA1 receptor could offer a potential treatment for conditions such as inflammatory or neuropathic pain,
Gijsen, Harrie J.M.,Berthelot, Didier,De Cleyn, Michel A.J.,Geuens, Ivo,Brone, Bert,Mercken, Marc
scheme or table
p. 797 - 800
(2012/03/11)
3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS
The present invention is related to novel 3,4-dihydropyrimidine compounds of formula (I) having TRPA1 receptor antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use
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Page/Page column 25
(2009/12/28)
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