Synthesis and antihyperglycemic evaluation of various protoberberine derivatives
Various berberine derivatives (2-17) were synthesized and their antihyperglycemic activities were evaluated in a model of β-cell-membrane chromatography and a model of alloxan-induced diabetes mice. The results indicated that compounds 5 and 14 exhibited antihyperglycemic activity. Their structure-activity relationships were discussed.
Bian, Xiaoli,He, Langchong,Yang, Guangde
p. 1380 - 1383
(2007/10/03)
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