Cross-linked crystals of subtilisin: Versatile catalyst for organic synthesis
Cross-linked enzyme crystals (CLECs) of subtilisin exhibit excellent activity in aqueous and various organic solvents. This catalyst is more stable than the native enzyme in both aqueous and mixed aqueous/organic solutions. Subtilisin-CLEC was shown to be a versatile catalyst. It was used for the syntheses of peptides and peptidomimetics, mild hydrolysis of amino acid and peptide amides, enantio- and regioselective reactions, and transesterifications.
Wang, Yi-Fong,Yakovlevsky, Kirill,Zhang, Bailing,Margolin, Alexey L.
p. 3488 - 3495
(2007/10/03)
Enzymatic Resolution of Racemic Amines: Crucial Role of the Solvent
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Kitaguchi, Hiroshi,Fitzpatrick, Paul A.,Huber, Joel E.,Klibanov, Alexander M.
p. 3094 - 3095
(2007/10/02)
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