Synthesis and Isomeric Conversions of Several 2-Substituted 1,4-Dihydro-4-oxo-3-quinolinecarboxylic Acid Derivatives
Ethyl ester derivatives of 6- and 8-substituted 2-methyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids have been synthesized by treatment of the diethyl ester of acetylmalonic acid with 2- or 4-substituted anilines.Condensation of these newly synthesized quinolinecarboxylic acid derivatives with 4-nitrobenzaldehyde resulted in the formation of 6- and 8-substituted 2--1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and ethyl esters of 6- and 8-substituted 2--4-acetoxy-3-quinolinecarboxylic acids.The tautomeric and conformational transformations of these newly synthesized compounds have also been investigated, using IR, NMR, and UV spectroscopy.
Kononov, L. I.,Veinberg, G. A.,Liepin'sh, E. E.,Dipan, I. V.,Sukhova, N. M.,Lukevits, E.
p. 765 - 771
(2007/10/02)
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