Palladium-Catalyzed gem-Difluoroallylation Reaction between Aryltributyltin and Bromodifluoromethylated Alkenes
A robust Stille gem-difluoroallylation of arylstannanes with 3-bromo-3,3-difluoropropenes has been established. The catalyst was found to exert critical effect on the reaction chemoselectivity. By using Pd(OH)2/C as the catalyst, a series of 3-(hetero)ary
Chen, Xiao-Qu,Lu, Heng,Chen, Chuan-Xin,Zeng, Ruoqing,Wang, Dong-Yu,Shi, Chang-Yun,Zhang, Ao
supporting information
p. 2935 - 2946
(2022/02/10)
PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS
Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): Formula (I) wherein R', R2, L', and L2 are as defined herein.
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Page/Page column 4
(2019/03/05)
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