cas 1206524-85-7, MK-5172 | Articles data

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1206524-85-7

Articles about 1206524-85-7Total 7 be found

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Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus
An efficient synthesis of grazoprevir is reported. Starting from four readily available building blocks, grazoprevir is prepared in 51% overall yield and >99.9% purity for pharmaceutical use.
Xu, Feng,Kim, Jungchul,Waldman, Jacob,Wang, Tao,Devine, Paul
p. 7261 - 7265
(2018/11/23)

METHODS AND INTERMEDIATES FOR PREPARING MACROLACTAMS
The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
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(2015/05/05)

Inhibitors of nedd8-activating enzyme
The invention relates to an administration unit comprising crystalline form I of {(1 S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate (I-216) hydrochloride salt and to a packaging comprising the administration unit according to the invention.
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(2014/08/20)

Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172
The development of a practical, asymmetric synthesis of the hepatitis C virus (HCV) protease inhibitor MK-5172 (1), an 18-membered macrocycle, is described.
Kuethe, Jeffrey,Zhong, Yong-Li,Yasuda, Nobuyoshi,Beutner, Gregory,Linn, Katherine,Kim, Mary,Marcune, Benjamin,Dreher, Spencer Douglas,Humphrey, Guy,Pei, Tao
p. 4174 - 4177
(2013/09/12)

CRYSTAL FORMS OF A HCV PROTEASE INHIBITOR
The present invention relates to different forms of a HCV inhibitory compound.
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(2013/03/26)

Discovery of MK-5172, a macrocyclic hepatitis C virus NS3/4a protease inhibitor
A new class of HCV NS3/4a protease inhibitors containing a P2 to P4 macrocyclic constraint was designed using a molecular modeling-derived strategy. Building on the profile of previous clinical compounds and exploring the P2 and linker regions of the series allowed for optimization of broad genotype and mutant enzyme potency, cellular activity, and rat liver exposure following oral dosing. These studies led to the identification of clinical candidate 15 (MK-5172), which is active against genotype 1-3 NS3/4a and clinically relevant mutant enzymes and has good plasma exposure and excellent liver exposure in multiple species.
Harper, Steven,McCauley, John A.,Rudd, Michael T.,Ferrara, Marco,DiFilippo, Marcello,Crescenzi, Benedetta,Koch, Uwe,Petrocchi, Alessia,Holloway, M. Katharine,Butcher, John W.,Romano, Joseph J.,Bush, Kimberly J.,Gilbert, Kevin F.,McIntyre, Charles J.,Nguyen, Kevin T.,Nizi, Emanuela,Carroll, Steven S.,Ludmerer, Steven W.,Burlein, Christine,Dimuzio, Jillian M.,Graham, Donald J.,McHale, Carolyn M.,Stahlhut, Mark W.,Olsen, David B.,Monteagudo, Edith,Cianetti, Simona,Giuliano, Claudio,Pucci, Vincenzo,Trainor, Nicole,Fandozzi, Christine M.,Rowley, Michael,Coleman, Paul J.,Vacca, Joseph P.,Summa, Vincenzo,Liverton, Nigel J.
p. 332 - 336
(2012/06/01)

Macrocyclic Quinoxaline Compounds as HCV NS3 Protease Inhibitors
The present invention relates to macrocyclic a compound of formula (I) and its use as inhibitors of the hepatitis C virus (HCV) NS3 protease, and in treating or preventing HCV infections.
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Page/Page column 10

(2010/03/02)

Chemical Properties

Boiling Point: 824.997 °C at 760 mmHg
Flash Point:452.742 °C
Density: 1.331 g/cm³
Solubility:Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol
Storage Temp.:Sealed in dry,Store in freezer, under -20°C
PKA: 3.23±0.40(Predicted)
PSA: 143.67000
LogP: 3.29510

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1206524-85-7

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Chemical Properties

Boiling Point: 824.997 °C at 760 mmHg

Flash Point:452.742 °C

Density: 1.331 g/cm³

Solubility:Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol

Storage Temp.:Sealed in dry,Store in freezer, under -20°C

PKA: 3.23±0.40(Predicted)

PSA: 143.67000

LogP: 3.29510

Global suppliers and manufacturers of 1206524-85-7total 53 suppliers on LookChem

Article Database

1206524-85-7

Articles about 1206524-85-7Total 7 be found

More Articles about upstream products of 1206524-85-7

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Chemical Properties

Boiling Point: 824.997 °C at 760 mmHg

Flash Point:452.742 °C

Density: 1.331 g/cm3

Solubility:Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol

Storage Temp.:Sealed in dry,Store in freezer, under -20°C

PKA: 3.23±0.40(Predicted)

PSA: 143.67000

LogP: 3.29510

Global suppliers and manufacturers of 1206524-85-7total 53 suppliers on LookChem

Density: 1.331 g/cm³