- Synthesis of 2,3,4-trisubstituted pyrroles via a facile reaction of vinyl azides and tosylmethyl isocyanide
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A facile synthesis of polysubstituted pyrroles from tosylmethyl isocyanide (TOSMIC) and readily synthesized vinyl azides was developed. The reaction proceeded under mild conditions in the presence of base. 2-Tosyl-substituted pyrroles were obtained in moderate to good isolated yields. Additionally, a base-initiated one-pot pyrrole synthesis also was developed using carboxaldehydes, ethyl 2-azidoacetate, and TOSMIC.
- Chen, Wenteng,Shao, Jiaan,Li, Zhi,Giulianotti, Marc A.,Yu, Yongping
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body text
p. 214 - 221
(2012/03/07)
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- Copper-catalyzed tandem synthesis of [1,2,3]triazolo[5,1-a]isoquinolines and their transformation to 1,3-disubstituted isoquinolines
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2-Azido-3-(2-iodophenyl)acrylates react with terminal alkynes in the presence of a copper(II) catalyst without ligands to give a wide range of [1,2,3]triazolo[5,1-a]isoquinolines in good yields. These compounds favor expulsion of N2 in refluxed acetic acid to form 1,3-disubstituted isoquinolines. The procedure is simple, economical, and efficient.
- Hu, Yuan-Yuan,Hu, Jie,Wang, Xiang-Chuan,Guo, Li-Na,Shu, Xing-Zhong,Niu, Yan-Ning,Liang, Yong-Min
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supporting information; experimental part
p. 80 - 86
(2010/03/04)
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