Synthesis and Cardiac Electrophysiological Activity of N-Substituted-4-(1H-imidazol-1-yl)benzamides-New Selective Class III Agents
The synthesis and cardiac electrophysiological activity of 18 N-substituted imidazolylbenzamides or benzenesulfonamides are described.Compounds 6a,d,f-k and 11 exhibited potency in the in vitro Purkinje fiber assay comparable to that of N-2-(diethylamino
Morgan, Thomas K.,Lis, Randall,Lumma, William C.,Nickisch, Klaus,Wohl, Ronald A.,et al.
p. 1091 - 1097
(2007/10/02)
Substituted 4-(1H-imidazol-1-yl)benzamides as antiarrhythmic agents
Novel substituted 4-[1H-imidazol-1-yl]benzamides and their use in the treatment of cardiac arrthythmias especially as Class III or combination Class I/III antiarrhythmic agents is described. Pharmaceutical formulations containing such compounds are also d
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(2008/06/13)
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