- Preparation method of chiral morpholine compound
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The invention provides a preparation method of a chiral morpholine compound. With chiral ethylene oxide as a raw material, the preparation method comprises the steps of ring opening, cyclization and deprotection reaction to obtain the chiral 2-substituted morpholine compound. The preparation process is simple and environmentally friendly, has mild reaction conditions, is free of irritation or allergens, has higher total yield and good safety and is suitable for industrial amplification.
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- COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS
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The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-fu
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Page/Page column 33-34
(2008/06/13)
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- Compounds and compositions as inhibitors of receptor tyrosine kinase activity
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The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, and/or PFGFRα kinase
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Page/Page column 16-18
(2010/02/11)
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- Synthesis and Reaction of Optically Active Morpholinones
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The reactions of variously substituted chiral morpholin-2-and-3-ones chemoselectively synthesized from chiral amino acids and lactic acid as the chiral source are described.
- Kashima, Choji,Harada, Kazuo
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p. 1521 - 1526
(2007/10/02)
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