- Troxerutin amide derivative as well as synthetic method and use thereof
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The invention discloses a troxerutin amide derivative as well as a synthetic method and use thereof, belonging to the medicinal chemistry field. The method comprises the step of respectively reacting troxerutin vinyl ester as a raw material with a 1,2,3,4
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Paragraph 0060; 0061; 0062
(2017/10/07)
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- Regioselective enzymatic acylation of troxerutin in nonaqueous medium
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A series of monosubstituted troxerutin esters have been synthesized by enzyme-catalyzed regioselective acylation of troxerutin in nonaqueous medium. Using divinyl dicarboxylates (CH2{double bond, long}CH{single bond}OOC{single bond}(CH2)n{single bond}COO{single bond}CH{double bond, long}CH2, n = 2, 3, 4, 7, 8, 11) featuring different chain length as acyl donors and alkaline protease from Bacillus subtilis as catalyst, troxerutin was regioselective acylated at B' ethoxyl group. The results indicated that the regioselectivity of the enzyme-catalyzed acylation was not affected by the chain length of the acyl donor.
- Xiao, Yong Mei,Mao, Pu,Zhao, Zhen,Yang, Liang Ru,Lin, Xian Fu
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scheme or table
p. 59 - 62
(2010/11/16)
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