- Traceless approach for the synthesis of 3,5-disubstituted thiohydantoins on functionalized ionic-liquid support
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A traceless approach for the synthesis of 3,5-disubstituted thiohydantoins on a novel functionalized ionic-liquid support, 5, is described. Acylation of benzylamine functionalized ionic-liquid support with amino acids yielded ionic-liquid-supported amino acids, which reacted with isothiocyanates to afford ionic-liquid-supported thioureas. Following intramolecular cyclization cleavage from the ionic-liquid support by trifluoroacetic acid (TFA), the desired 3,5-disubstituted thiohydantoins were obtained in good yields and purities. The efficiency of this ionic-liquid-phase strategy facilitated isolation and analysis of intermediates and removal of excess reagents and by-products during the reaction process.
- Yao, Chao,Zhang, Yandong,Zhang, Guolin,Chen, Wenteng,Yu, Yongping,Houghten, Richard A.
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p. 717 - 724
(2011/03/19)
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