- Design, synthesis, and biological evaluation of 1,5-diaryl-1,2,4-triazole derivatives as selective cyclooxygenase-2 inhibitors
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A series of 1,5-diaryl-1,2,4-triazole derivatives were synthesized and evaluated as cyclooxygenase-2 (COX-2) inhibitors. The results of the preliminary biological assays in vivo showed that eight compounds 5b, 6b, 6c, 7c, 8b, 8d, 9c, and 9d have potent an
- Jiang, Bo,Zeng, Yi,Li, Meng-Jie,Xu, Jin-Yi,Zhang, Yong-Na,Wang, Qiu-Juan,Sun, Ni-Yue,Lu, Tao,Wu, Xiao-Ming
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p. 500 - 508
(2011/05/07)
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