Direct synthesis of Cbz-protected (2-amino)-6-(2-aminoethyl)pyridines
A novel series of (2-amino)-6-(2-aminoethyl)pyridines were prepared by a convenient Suzuki-Miyaura coupling approach from 2-amino-6-bromopyridines. Benzyl vinylcarbamate was first treated with 9-BBN followed by aqueous NaOH and then the appropriate bromopyridine precursors were added into the mixture. The mixture was finally heated in presence of a palladium catalyst to provide the corresponding products in overall high yields. The procedure is extended to the preparation of related pyrazine and pyrimidine compounds as well as (2-amido)- and (2-alkoxy)-6-(2-aminoethyl)pyridines.
Roy, Sudipta,Zych, Andrew J.,Herr, R. Jason,Cheng, Cliff,Shipps Jr., Gerald W.
experimental part
p. 1973 - 1979
(2010/04/24)
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