- Synthetic studies directed towards various homologues of natural Sesquiterpene-Coumarin ethers: The Domino approach
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A domino-based strategy was used to construct analogues containing the basic skeleton of the monocyclic sesquiter-pene-coumarin ethers galbanic acid (1) and secodrial (3), through conversion of the domino adduct 19 into 10 and 11, chosen as representative targets. 1H NMR patterns, corroborated by X-ray crystallographic analysis for two of the four possible diastereomeric arrangements of the six-membered B-ring common to various A-seco terpenes, have been determined. The observed trends help in the design of substituent combinations that provide a tool for diastereomeric recognition, depending on the cis/trans arrangement of the adjacent methyl groups and the adopted conformations.
- Corbu, Andrei,Castro, Juan M.,Aquino, Maurizio,Gandara, Zoila,Retailleau, Pascal,Arseniyadis, Simeon
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supporting information; experimental part
p. 1483 - 1493
(2010/06/13)
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