- 4-substituted 1,2,4-triazole derivatives
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A discrete class of 4-substituted 1,2,4-triazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
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- 4-Substituted 1,2,4-triazole derivatives
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4-substituted 1,2,4-triazole derivatives of formula I: wherein R represents a 2-(dimethylamino)ethyl group, or a group of formula (i) or (ii): or a salt or prodrug thereof;, are selective agonists of 5-HT1-like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.
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- GABA Agonists and Uptake Inhibitors. Synthesis, Absolute Stereochemistry, and Enantioselectivity of (R)-(-)- and (S)-(+)-Homo-β-proline
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The cyclic analogue of 4-aminobutyric acid (GABA), 3-pyrrolidineacetic acid (homo-β-proline), is a potent agonist at GABAA receptors, it interacts effectively with GABA-uptake mechanisms, and it is a moderately potent inhibitor of GABAB/s
- Nielsen, Lone,Brehm, Lotte,Krogsgaard-Larsen, Povl
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