- Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones
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A series of spiro hydantoins derived from 8-azachromanones (2,3-dihydro-4H-pyrano[2,3-b]pyridin-4-ones) has been prepared and tested for aldose reductase inhibitory activity. The standard Bucherer-Bergs conditions had to be drastically modified to increas
- Sarges,Goldstein,Welch,Swindell,Siegel,Beyer
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p. 1859 - 1865
(2007/10/02)
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- Azolidinedione derivatives
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A series of novel spiro-deteroazolones derived from a 2,3-dihydropryrano[2,3-b]pyridine ring system have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Typical member compounds include spiro-imides, spiro-oxazolidinediones, spiro-thiazolidinediones and spiro-imidazolidinediones derived from the aforesaid ring system. (4'S) (2'R)-6'-Chloro-2',3'-dihydro-2'-methyl-spiro-[imidazolidine-4,4'-4'H-pyrano[2,3-b]pyridine]-2,5-dione represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided.
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- Azolidinedione derivatives
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Spiro-heteroazolones of formula wherein, Z is methylene, oxygen, sulfur or imino; Y is oxygen or sulfur; and -A=B-D=E- represents -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH or -CH=CH-CH=N-, or an N-oxide derivative thereof. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Typical member compounds include spiro-imides, spiro-oxa-zolidinediones, spiro-thiazolidinediones and spiro-imidazolidinediones derived from the aforesaid ring system. (4'S)(2'R)-6'-Chloro-2',3'-dihydro-2'-methyl--spiro-[imidazolidine-4,4'-4'H-pyrano[2,3-b]pyridine]--2,5-dione represents a typical and preferred member compound. Methods for preparing all these compounds from known starting materials are provided.
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