1,4-Substituted 2,3-dihydropyrrolo[3,2-c]quinolines which are inhibitors of H+ K+ ATPase activity and useful as inhibitors of gastric acid secretion. A compound of the invention is 1-(2-methylphenyl)-4-amino-6-methyl-2,3-dihydropyrrolo[3,2-c]quinoline.
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(2008/06/13)
Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 1. 1-Aryl-4-methylpyrroloquinolines as Conformationally Restrained Analogues of 4-(Arylamino)quinolines
The 4-(arylamino)quinoline 4, previously described as an antiulcer compound, is shown to be an inhibitor of the gastric (H+/K+)-ATPase.It is postulated that 1-arylpyrroloquinolines 6 act as conformationally restrained analogue
Brown, Thomas H.,Ife, Robert J.,Keeling, David J.,Laing, Shiona M.,Leach, Colin A.,et al.
p. 527 - 533
(2007/10/02)
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