- Diastereoselective lithiation of n-silyl-protected (S)-tetrahydro-1H- pyrrolo[1,2-c]imidazol-3(2H)-one
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An L-proline-derived imidazolone protected with an N-triethylsilyl (N-TES) group undergoes diastereoselective lithiation-electrophile quench to give C5-substituted products with syn stereochemistry. Unlike the previous N-t-Bu analogues, the N-TES derivatives may be easily N-desilylated to give secondary ureas that serve as precursors to N-phenyl chiral bicyclic guanidines.
- Metallinos, Costa,Sadraei, Seyed Iraj,Zhukovskaya, Nadezda
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- Silica gel-immobilized multidisciplinary materials applicable in stereoselective organocatalysis and HPLC separation
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In this pilot study, we present novel bifunctional silica gel-immobilized materials applicable as heterogeneous organocatalysts and stationary phases in HPLC. The materials provided high stereoselectivity in both batch and continuous flow catalysis of a m
- T?ma,Kohout
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p. 1174 - 1181
(2018/01/17)
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- QUINOLINE AND QUINAZOLINE DERIVATIVES HAVING AFFINITY FOR 5HT1-TYPE RECEPTORS
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Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.
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Page/Page column 103
(2008/06/13)
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