- A 2 - (5 - fluoro - 2, 4 - two-nitrobenzene oxygen) acetate preparation method
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The invention belongs to the field of organic synthetic technology, in particular to a 2 - (5 - fluoro - 2, 4 - two-nitrobenzene oxygen) acetate preparation method, comprises the following steps: step 1, to 2, 4 - difluoro nitrobenzene is used as raw mate
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Paragraph 0062; 0064
(2019/01/08)
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- Production method of flumioxazin
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The invention discloses a production method of flumioxazin. The production method comprises the following steps: by using 2,4-difluoronitrobenzene as an initial raw material, sequentially carrying out nitrification to obtain 1,5-difluoro-2,4-dinitrobenzene, and carrying out etherification reaction on the 1,5-difluoro-2,4-dinitrobenzene and butyl hydroxyacetate to obtain butyl 3-fluoro-4,6-dinitrophenoxyacetate; carrying out reduction cyclization with hydrogen to obtain 7-fluoro-6-amino-2H-1,4-benzoxazinyl-3(4H)-one; under alkaline conditions, carrying out alkynylation reaction with propargyl chloride to obtain an intermediate product; and finally, carrying out amidation reaction with 3,4,5,6-tetrahydrophthalic anhydride to obtain the flumioxazin. The production technique of the method has the advantages of short process, mild reaction conditions and cheap and accessible raw materials, and is convenient to operate; and the solvent used in the preparation process is recyclable. The method also has the advantages of high total reaction yield, high product purity, low production cost and low environmental pollution.
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Paragraph 0041; 0047; 0048; 0049
(2017/01/26)
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- Synthesis of a Fluorobenzoxazine Derivative and Its Analogues
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Syntheses of a fluorobenzoxazine derivative, fluorobenzothiazine derivative and fluoroquinoxaline derivative are described.These compounds were synthesized by reductive cyclization of the corresponding fluorodinitrobenzene derivatives.The fluorobenzoxazin
- Takemoto, Ichiki,Yamasaki, Kaori,Kaminaka, Hiroshi
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p. 788 - 789
(2007/10/02)
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