- PYRIMIDINE AND FIVE-MEMBERED NITROGEN HETEROCYCLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USES THEREOF
-
The present invention relates to a pyrimidine and a five-membered nitrogen heterocycle derivative, a preparation method therefor, and the medical uses thereof. Particularly, the present invention relates to a pyrimidine and a five-membered nitrogen hetero
- -
-
-
- REGULATOR OF NITROGEN-CONTAINING HETEROAROMATIC DERIVATIVES, PREPARATION METHOD THEREFOR AND USE THEREOF
-
The present invention relates to a regulator of nitrogen-containing heteroaromatic derivatives, a preparation method therefor and the use thereof. In particular, the present invention relates to a compound as shown in the general formula (I), a preparation method therefor and a pharmaceutical composition containing the compound, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer, wherein the definition of each substituent in the general formula (I) is the same as that in the description.
- -
-
Paragraph 0109; 0918-0921
(2021/08/27)
-
- Salt of nitrogen-containing heteroaromatic derivative and crystal form thereof
-
The invention relates to a salt of a nitrogen-containing heteroaromatic derivative and a crystal form thereof. The invention specifically relates to a salt with a general formula (I) and a crystal form thereof. A preparation method and a pharmaceutical composition containing the salt of the derivative and a crystal form thereof, as a protein tyrosine phosphatase - 2C (SHP2) inhibitor, and application thereof to treatment of diseases or diseases such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colon cancer.
- -
-
Paragraph 1220-1226
(2021/10/13)
-
- A SYNTHESIS OF SOME PYRIDINYLPYRIMIDINES FROM KETENEDITHIOACETALS
-
Some studies are reported on the preparation of a new class of substituted 5-(2-pyridinyl)pyrimidines, starting with cyano(2-pyridinyl)ketenedithioacetal.This has been reacted with amidines under base-catalysed conditions, giving a variety of different pr
- Katz, Ruth B.,Mitchell, Michael B.,Sammes, Peter G.,Ife, Robert J.
-
p. 1801 - 1814
(2007/10/02)
-
- IMIDAZOLYLMETHYLTHIOETHYL DITHIOCARBAMATE COMPOUNDS
-
The compounds are dithiocarbamates and isothioureas which are histamine H 2-antagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]-N-cyano-N'-methylisothiourea.
- -
-
-