STRIKING INFLUENCE OF THE REACTION CONDITIONS ON THE STEREOSELECTIVITY IN ELECTROPHILIC SUBSTITUTION OF A 10-LITHIO-ERGOLINYL-UREA
The regioselectivity of the deprotonation of the 8α-ergolinyl-urea 1 (terguride) depends on the substituent at the indole nitrogen.A tert.-butyl-dimethylsilyl (TBDMS) protecting group facilitates the removal of the angular benzylic proton in position 10.The reaction of the 10-lithio compound 5 with electrophiles affords cis or trans fused products, depending on reagent and reaction conditions.
Get Best Price for122888-33-9(6aR,9S,10aR)-4-(tert-Butyl-dimethyl-silanyl)-9-(3,3-diethyl-ureido)-7-methyl-6,6a,7,8,9,10-hexahydro-4H-indolo[4,3-fg]quinoline-10a-carboxylic acid phenylamide