- Ruthenium-catalyzed pyrrole synthesis via oxidative annulation of enamides and alkynes
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An efficient and regioselective ruthenium-catalyzed oxidative annulation of enamides with alkynes via the cleavage of C(sp2)-H/N-H bonds is reported. The reactions can afford N-acetyl substituted or N-unsubstituted pyrroles by altering the reaction conditions slightly.
- Li, Bin,Wang, Nuancheng,Liang, Yujie,Xu, Shansheng,Wang, Baiquan
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supporting information
p. 136 - 139
(2013/03/28)
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- On the selectivity in some Rh(III) catalyzed C-H activation cross-couplings
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In the last few years, Rh(III)-catalyzed CH functionalizations have made tremendous progress and, consequently, have recently received increasing attention. These CH activation reactions, generally involving a chelate assisting directing group, have been utilized to form valuable heterocycles and to run useful coupling reactions. In this paper, three different transformations are presented and discussed. In order to unequivocally determine the stereochemistry of some of these transformations, crystal structural analysis data are provided.
- Patureau, Frederic William,Besset, Tatiana,Fr?hlich, Roland,Glorius, Frank
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p. 1081 - 1085
(2013/02/23)
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- Pyrrole synthesis via allylic sp3 C-H activation of enamines followed by intermolecular coupling with unactivated alkynes
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A conceptually novel pyrrole synthesis is reported, efficiently merging enamines and (unactivated) alkynes under oxidative conditions. In an intermolecular Rh catalyzed process, the challenging allylic sp3 C-H activation of the enamine substrates is followed by the cyclization with the alkyne (R3 = CO2R). Alternatively, in some cases (R 3 = CN), the enamine can be utilized for a vinylic sp2 C-H activation. A total of 17 examples with yields above 60% is presented, together with the results of an initial mechanistic investigation.
- Rakshit, Souvik,Patureau, Frederic W.,Glorius, Frank
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supporting information; experimental part
p. 9585 - 9587
(2010/09/10)
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