Synthesis and SAR of adatanserin: Novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT2 activity as potential anxiolytic and antidepressant agents
Several novel functionalized adamantyl aryl- and heteroarylpiperazine derivatives were prepared and examined in various receptor binding and behavioral tests to determine their serotonin receptor activities. Many compounds demonstrated modest to high affi
Abou-Gharbia, Magid A.,Childers Jr., Wayne E.,Fletcher, Horace,McGaughey, Georgia,Patel, Usha,Webb, Michael B.,Yardley, John,Andree, Terrance,Boast, Carl,Kucharik Jr., Robert J.,Marquis, Karen,Morris, Herman,Scerni, Rosemary,Moyer, John A.
p. 5077 - 5094
(2007/10/03)
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